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Blastocyst Embryo Transfer
IVF embryos are usually transferred on the second or third day following egg retrieval at the four-to-eight cell stage. The IVF embryos must continue to grow for two or three more days to reach the blastocyst transfer stage (50-150 cells) before they are ready for implantation into the uterine wall (endometrium).
Recent advances in IVF laboratory treatments have allowed for the successful culture of embryos to the blastocyst stage.
Blastocysts may have a better potential to implaint into the uterine wall than earlier stage embryos. Many embryos stop growing at the four-to- eight cell stage, probably because of some inherent problem. Therefore, fewer embryos will have the ability to grow to the blastocyst stage. Those that successfully reach the blastocyst stage are probably more developmentally competent than earlier stage embryos. As well, their stage of development when replaced into the uterus is very similar to what it would be in a natural conception cycle.
WHAT ARE THE PROS & CONS OF BLASTOCYST EMBRYO TRANSFER?
The advantage of attempting to grow embryos to the blastocyst stage is that they should have a greater chance of implantation because the stage of embryo development matches the uterine environment. As a result, fewer embryos can be replaced which will minimize the risk of a multiple pregnancy.
The disadvantage of attempting to grow embryos to the blastocyst stage is that fewer embryos will "survive" or grow to this stage (probably about 30 - 50% of the embryos). There is a possibility (up to 10%) that none will reach the blastocyst transfer stage and therefore, no embryos will be available for transfer. The availability of "extra" embryos for freezing is also significantly reduced. There is an additional fee for blastocyst transfer.
WHO IS ELIGIBLE FOR BLASTOCYST EMBRYO TRANSFER?
Couples who have had unsuccessful prior attempts with IVF or IVF/ICSI despite having many good quality eggs retrieved are being offered blastocyst culture as an alternative treatment. The ability to select the most viable embryos for transfer &implantation should improve their chance of achieving a pregnancy.
The embryos will be cultured in the IVF laboratory for 5 to 6 days after egg retrieval. At least 4 good quality embryos (6 to 8 cells) should be available on the third day after egg retrieval to maximize the chances of obtaining a blastocyst.
CONFIDENTIALITY
Please be assured that all services are provided in a completely discreet and confidential environment.
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