Proudly part of the City Fertility Network
Proudly part of the City Fertility Network
Implantation failure is one of the major challenges in fertility treatment and a receptive endometrium plays a key role in successful implantation and pregnancy.
Platelet-Rich Plasma (PRP) therapy is used to help improve the uterine lining (endometrial) thickness and/or the endometrial receptivity to improve pregnancy outcomes. PRP Treatment may be recommended for patients who have experienced recurrent implantation failure over multiple IVF cycles or those with a persistently thin endometrium.
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Platelet-Rich Plasma (PRP) therapy uses a concentration of your own platelets, rich in growth factors and proteins—to support the regeneration and repair of tissues. In fertility treatment, platelet rich plasma is introduced into the uterus to improve the endometrial lining, making it thicker and more receptive for embryo implantation. A fertility specialist may recommend this for patients with a thin endometrium, patients with repeated implantation failure, or multiple unsuccessful IVF cycles and patients with surgically treated Asherman’s syndrome.
PRP fertility treatment is a specialised fertility treatment that requires expertise and precision. City Fertility is one of a few clinics in Australia offering PRP reflecting our commitment to innovation and excellence in fertility care. It is an emerging adjunctive therapy and not offered at all City Fertility clinics. To discuss your options, please make an appointment to speak to one of our fertility specialists.
Your fertility specialist may recommend PRP therapy.
Who is not suitable for PRP?
For those with recurrent implantation failure, PRP treatment is used to improve the receptivity of the endometrium prior to an embryo transfer and is usually performed 48 to 72 hours prior to a scheduled embryo transfer. For those with thin endometrium, PRP treatment is used to thicken the endometrium to beyond 6mm and requires two to three treatments four to five days apart.
The patient’s own blood plasma enriched with platelets is inserted into the uterine cavity, flushing the uterus with highly concentrated platelets (4-5 times more than circulating blood). Platelets contain multiple growth factors that are thought to play a key role in tissue regeneration, activation of cell growth and cellular renewal. When highly concentrated platelets are administered into the uterine cavity, they ‘activate’ and produce an inflammatory response, increasing blood flow and healing factors in the surrounding tissue.
PRP is a safe, quick and straightforward procedure. There is a an extremely small risk of developing an infection. Antibiotics are rarely needed. It is also important to know that only your own blood is used for PRP fertility treatment so there are no concerns with plasma rejection or adverse reactions.
At City Fertility, PRP is offered as an add-on treatment and is generally performed as part of an IVF cycle or a frozen embryo transfer (FET). Unfortunately, As PRP is considered an adjuvant therapy and it is not covered by Medicare. The cost per treatment is $300 – $450, depending on location.
If you are considering PRP, your fertility specialist will advise whether it may be beneficial in your specific circumstances and discuss the costs with you as part of your treatment planning.
At City Fertility, PRP is offered as an add-on treatment and is generally performed as part of an IVF cycle or a frozen embryo transfer (FET). Unfortunately, PRP is considered an adjuvant therapy and is not covered by Medicare. The cost per treatment is $300 – $450, depending on location.
If you are considering PRP, your fertility specialist will advise whether it may be beneficial in your specific circumstances and discuss the costs with you as part of your treatment planning.
The effects of uterine PRP treatment are thought to be most active in the weeks following the injection, supporting endometrial growth and receptivity during that cycle. In most cases, PRP is timed to coincide with embryo transfer or endometrial preparation and is not considered a long-term treatment. If the desired outcome is not achieved, a repeat treatment may be considered in the following cycle, based on clinical advice.
PRP is administered during the follicular phase of an IVF or frozen embryo transfer cycle or at a time that aligns with endometrial preparation (endometrial preparation phase). Your fertility specialist will advise the most suitable timing, but in many cases, PRP is done 48–72 hours before embryo transfer or as part of a tailored cycle plan.
In the lead-up to and after your PRP treatment, your fertility specialist may recommend avoiding anti-inflammatory medications such as ibuprofen or aspirin, unless specifically prescribed. This is because inflammation is part of the healing response PRP is designed to support. Always inform your specialist of any medications or supplements you are taking so they can guide you appropriately and ensure optimal conditions for the treatment to work.
Effectiveness is typically monitored through ultrasound assessments of the endometrial lining. Your specialist may look for improvements in endometrial thickness, pattern and receptivity ahead of embryo transfer. Since PRP is still considered an emerging treatment, your response will be evaluated over time, and your care plan may be adjusted accordingly to improve your chances of success.
