Assisted hatching for IVF

Laser-assisted hatching

Laser-assisted hatching is a scientific IVF technique that can make it easier for the embryo to “hatch” or breakthrough its outer layer or “shell” (a membrane also known as the zona pellucida) by creating an opening. In some situations, this layer is abnormally thick and/or hardened with the freezing and thawing process among the contributing factors. The less difficulty the embryo has in hatching, the better its chance of attaching or implanting into the wall of the uterus.

Pregnancy cannot occur unless the embryo hatches and implants, and laser-assisted hatching can play a key role in achieving these crucial steps.


Treatment procedure

The procedure involves an embryologist sending a brief, strong light beam, under a microscope, to create a gap in the shell through which the embryo can come out. This is usually done three days after fertilisation has occurred during an IVF or Intracytoplasmic Sperm Injection (ICSI) cycle, which is when the embryo has begun to cleave (divide). It takes only a few seconds and does not harm the embryo. The embryo is then transferred back into the patient’s uterus to attach itself to the lining and continue growing.


Who is assisted hatching recommended for?

Any patient can take advantage of laser-assisted hatching, but those most likely to be best suited are those who:

  • Are above the age of 37
  • Produce a high level of Follicle
  • Stimulating Hormone (FSH) early in their cycle
  • Have had unsuccessful IVF cycles
  • Have a tendency to produce a harder and/or thicker zona pellucida


Advantages of laser-assisted hatching

A laser has been shown to be superior to other forms of assisted hatching (chemical and manual) thanks to several advantages:

  • Minimal handling of the embryo
  • Fast and exact control over drilling of the shell opening
  • It is gentle and safe, with no negative effects on the embryo
  • Wide availability to patients, and offered under clinical guidance depending on your particular circumstances


To find out more about the blastocyst embryo transfer, please read our fact sheet: Laser-assisted hatching.




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